Natives who practice Kambo are Panoan-speaking indigenous groups in the southeast Amazon rainforest, such as the Mayoruna, Matses, Amahuaca, Kashinawa, Katukina, Yawanawá, and the Kaxinawá. Traditional practitioners claim that it aids fertility, cleanses the body and soul, increases strength, and brings good luck to hunts. The secretions are also commonly used in people who suffer from tikish or laziness: a condition perceived as unfavorable by the Noke Kuin as the person stops participating socially. It’s used by natives to expel “panema” (bad spirit) and to induce abortions.
Since the mid-20th-century, Kambo has also been practiced in urban regions of Brazil. In 2004, Brazil banned the sale and marketing of Kambo. Import is illegal in Chile. Outside of South America, it first became famous as an alternative therapy in the late 2010s.